Drosophila centrosomin protein is required for male meiosis and assembly of the flagellar axoneme

被引：67

作者：

Li, KJ ^{[1
]}

Xu, EYJ ^{[1
]}

Cecil, JK ^{[1
]}

Turner, FR ^{[1
]}

Megraw, TL ^{[1
]}

Kaufman, TC ^{[1
]}

机构：

[1] Indiana Univ, Howard Hughes Med Inst, Dept Biol, Bloomington, IN 47405 USA

来源：

JOURNAL OF CELL BIOLOGY | 1998年 / 141卷 / 02期

关键词：

D O I：

10.1083/jcb.141.2.455

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centrosomes and microtubules play crucial roles during cell division and differentiation. Spermatogenesis is a useful system for studying centrosomal function since it involves both mitosis and meiosis, and also transformation of the centriole into the sperm basal body. Centrosomin is a protein localized to the mitotic centrosomes in Drosophila melanogaster. We have found a novel isoform of centrosomin expressed during spermatogenesis. Additionally, an anticentrosomin antibody labels both the mitotic and meiotic centrosomes as well as the basal body. Mutational analysis shows that centrosomin is required for spindle organization during meiosis and for organization of the sperm axoneme, These results suggest that centrosomin is a necessary component of the meiotic centrosomes and the spermatid basal body.

引用

页码：455 / 467

页数：13

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