Lithium-induced increase in human brain grey matter

被引：492

作者：

Moore, GJ

Bebchuk, JM

Wilds, IB

Chen, G

Menji, HK

机构：

[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Radiol, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

来源：

LANCET | 2000年 / 356卷 / 9237期

关键词：

D O I：

10.1016/S0140-6736(00)02793-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.

引用

页码：1241 / 1242

页数：2

共 5 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].