Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli

被引：67

作者：

Ben-Ami, G

Ozeri, V

Hanski, E

Hofmann, F

Aktories, K

Hahn, KM

Bokoch, GM

Rosenshine, I

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Dept Mol Genet & Biotechnol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Dept Clin Microbiol, IL-91120 Jerusalem, Israel

[3] Univ Freiburg, Inst Pharmacol & Toxicol, Freiburg, Germany

[4] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 04期

关键词：

D O I：

10.1128/IAI.66.4.1755-1758.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enteropathogenic Escherichia coli (EPEC) induces formation of actin pedestals in infected host cells. Agents that inhibit the activity of Rho, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), compactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit formation of actin pedestals. In contrast, treatment of HeLa cells with ToxB inhibited EPEC invasion. Thus, Rho, Rac, and Cdc42 are not required for assembly of actin pedestals; however, they may be involved in EPEC uptake by HeLa cells.

引用

页码：1755 / 1758

页数：4

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