Activated protein C sensitivity ratio in pregnant women at delivery

被引：51

作者：

Mathonnet, F

deMazancourt, P

Bastenaire, B

Morot, M

Benattar, N

Beufe, S

Borg, JY

Giudicelli, Y

机构：

[1] CTR TRANSFUS SANGUINE YVELINES,LE CHESNAY,FRANCE

[2] BIOGENIC,MONTPELLIER,FRANCE

[3] CHU ROUEN,LABS GENET MOLEC,ROUEN,FRANCE

[4] CHU ROUEN,HEMOSTASE LAB,ROUEN,FRANCE

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 92卷 / 01期

关键词：

protein C; factor V; factor VIII; pregnancy; blood coagulation disorders;

D O I：

10.1046/j.1365-2141.1995.00271.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied activated protein C sensitivity ratio (APC-SR), factors V and VIII activity and von Willebrand antigen in control women, women using oral contraceptives, and pregnant women at delivery. The mean APC-SR of 2.4 in pregnant women was significantly lower than the mean APC-SR value of 3.5 for both the other groups and 45% of pregnant women had a ratio below the 5th percentile of the control group. None of them carried the R506-->Q mutation. This decreased ratio at delivery appeared to be connected, at least in part, with increased VIII activity. Thus, APC-SR at delivery should not be used to detect APC resistance.

引用

页码：244 / 246

页数：3

共 12 条

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