Isolation of austroinulin possessing cell cycle inhibition activity from Blumea glomerata and revision of its absolute configuration

被引：19

作者：

Ohtsuki, T

Koyano, T

Kowithayakorn, T

Yamaguchi, N

Ishibashi, M

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Temko Corp, Tokyo, Japan

[3] Khon Kaen Univ, Fac Agr, Dept Hort, Khon Kaen, Thailand

来源：

PLANTA MEDICA | 2004年 / 70卷 / 12期

关键词：

Blumea glomerata; Compositae; diterpene; cytotoxicity; cell cycle; austroinulin; absolute configuration;

D O I：

10.1055/s-2004-835847

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A labdane-diterpene, austroinulin (1), together with several known flavonoids and sesquiterpenes were isolated from leaves of Blumea glomerata (Compositae). Austroinulin (1) and most of the flavonoids showed cytotoxicity against HeLa cells, while austroinulin (1) exhibited a cell cycle inhibition effect at the G1 stage at the concentration of 15.2 mug/mL (47.2 muM). The absolute configuration of 1 was revised as 5S,6R,7S,8S,9R,10R on the basis of the modified Mosher's method.

引用

页码：1170 / 1173

页数：4

共 16 条

[1] SYNTHETIC STUDIES OF SESQUITERPENES WITH A CIS-FUSED DECALIN SYSTEM .4. SYNTHESIS OF (+)-5-BETA-H-EUDESMA-3,11-DIENE, (-)-5-BETA-H-EUDESMANE-4-BETA,11-DIOL AND (+)-5-BETA-H-EUDESMANE-4-ALPHA,11-DIOL, AND STRUCTURE REVISION OF A NATURAL EUDESMANE-4,11-DIOL ISOLATED FROM PLUCHEA-ARGUTA [J].