Structure of the DNA binding domain of E-coli SSB bound to ssDNA

被引：378

作者：

Raghunathan, S ^{[1
]}

Kozlov, AG ^{[1
]}

Lohman, TM ^{[1
]}

Waksman, G ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / 08期

关键词：

D O I：

10.1038/77943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coli (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 Angstrom. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes.

引用

页码：648 / 652

页数：5

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