MAP kinases and cell migration

被引：906

作者：

Huang, C

Jacobson, K

Schaller, MD ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF CELL SCIENCE | 2004年 / 117卷 / 20期

关键词：

cell migration; JNK; p38; Erk; paxillin; phosphorylation;

D O I：

10.1242/jcs.01481

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N.-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 (MAPKAP 2/3), which appears to be important for directionality of migration. Erk governs cell movement by phosphorylating myosin light chain kinase (MLCK), calpain or FAK. Thus, the different kinases in the MAPK family all seem able to regulate cell migration but by distinct mechanisms.

引用

收藏

页码：4619 / 4628

页数：10

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