Obesity and FTO: Changing Focus at a Complex Locus

被引：87

作者：

Tung, Y. C. Loraine ^{[1
]}

Yeo, Giles S. H. ^{[1
]}

O'Rahilly, Stephen ^{[1
]}

Coll, Anthony P. ^{[1
]}

机构：

[1] Univ Cambridge, Metab Res Labs, Med Res Council,Addenbrookes Hosp, Metab Dis Unit,Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ, England

来源：

CELL METABOLISM | 2014年 / 20卷 / 05期

基金：

英国医学研究理事会;

关键词：

BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; FUSED TOES FT; COMMON GENETIC-VARIANTS; FAT-MASS; ADULT OBESITY; ENERGY-INTAKE; FOOD-INTAKE; EUROPEAN POPULATIONS; CHILDHOOD OBESITY;

D O I：

10.1016/j.cmet.2014.09.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that obesity-associated SNPs appear functionally connected not with FTO but with two neighboring genes: IRX3 and RPGRIP1L. Here, we review these new findings and consider the implications for future analysis of GWAS hits.

引用

页码：710 / 718

页数：9

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