A general strategy towards the synthesis of 1-N-iminosugar type glycosidase inhibitors:: demonstration by the synthesis of D- as well as L-glucose type iminosugars (isofagomines)

被引：45

作者：

Pandey, G ^{[1
]}

Kapur, M ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Synth, Poona 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)01553-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of isofagomine, the potent glycosidase inhibitor of a type 1-N-iminosugar have been synthesized by the intramolecular cyclization of the PET generated alpha -trimethylsilylmethylamine radical cation with the appropriate tethered acetylene moiety. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：8821 / 8824

页数：4

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