Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population

被引:94
作者
Jung, H.-K.
Halder, S.
McNally, M.
Locke, G. R., III
Schleck, C. D.
Zinsmeister, A. R.
Talley, N. J.
机构
[1] Mayo Clin, Coll Med, Dyspepsia Ctr, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
[3] Ewha Womans Univ, Sch Med, Seoul 120750, South Korea
[4] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN 55905 USA
[5] Mayo Clin, Coll Med, Div Biostat, Rochester, MN 55905 USA
关键词
D O I
10.1111/j.1365-2036.2007.03366.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown. Aim To determine prevalence and risk factors for overlap of GERD and irritable bowel disease. Methods Population-based, cross-sectional survey was conducted by mailing a valid symptom questionnaire to eligible residents of Olmsted County, MN, aged 30-95 years. Irritable bowel syndrome were defined by Rome III; GERD was defined by weekly or more frequent heartburn and/or acid regurgitation. Results 2298 questionnaires returned (women 52%, 55% response). Irritable bowel syndrome and GERD occurred together more commonly than expected by chance; the prevalence of irritable bowel syndrome-GERD overlap, GERD alone and irritable bowel syndrome alone were 3%, 15% and 5% in men, and 4%, 14% and 10% in women, respectively. Predictors of irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone, and separately, GERD alone, were insomnia (OR 1.3, 95% CI: 1.06-1.70; OR 1.5, 95% CI: 1.13-1.90, respectively) and frequent abdominal pain (OR 3.9, 2.2-6.7; OR 1.8, 1.02-3.2, respectively). An additional predictor of irritable bowel syndrome-GERD overlap vs. GERD alone was higher somatization (OR 1.7, 1.1-2.4) and for irritable bowel syndrome-GERD overlap vs. irritable bowel syndrome alone was a higher body mass index (OR 1.0, 1.003-1.07). Conclusions Irritable bowel syndrome and GERD overlap is common in the population and does not occur by chance.
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页码:453 / 461
页数:9
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共 45 条
[1]  
Agréus L, 2001, AM J GASTROENTEROL, V96, P2905
[2]   Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction [J].
Akiho, H ;
Deng, MK ;
Blennerhassett, P ;
Kanbayashi, H ;
Collins, SM .
GASTROENTEROLOGY, 2005, 129 (01) :131-141
[3]   PSYCHOMETRIC PROPERTIES OF THE SUNYA REVISION OF THE PSYCHOSOMATIC SYMPTOM CHECKLIST [J].
ATTANASIO, V ;
ANDRASIK, F ;
BLANCHARD, EB ;
ARENA, JG .
JOURNAL OF BEHAVIORAL MEDICINE, 1984, 7 (02) :247-257
[4]  
BAKER LH, 1995, AM J GASTROENTEROL, V90, P1797
[5]   Enhanced preattentive central nervous system reactivity in irritable bowel syndrome [J].
Berman, SM ;
Naliboff, BD ;
Chang, L ;
FitzGerald, L ;
Antolin, T ;
Camplone, A ;
Mayer, EA .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2002, 97 (11) :2791-2797
[6]   Cognitive and emotional influences in anterior cingulate cortex [J].
Bush, G ;
Luu, P ;
Posner, MI .
TRENDS IN COGNITIVE SCIENCES, 2000, 4 (06) :215-222
[7]   A Community-Based, Controlled Study of the Epidemiology and Pathophysiology of Dyspepsia [J].
Castillo, Emma Janet ;
Camilleri, Michael ;
Locke, G. Richard, III ;
Burton, Duane D. ;
Stephens, Debra A. ;
Geno, Debra M. ;
Zinsmeister, Alan R. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2004, 2 (11) :985-996
[8]   Activation of the mucosal immune system in irritable bowel syndrome [J].
Chadwick, VS ;
Chen, WX ;
Shu, DR ;
Paulus, B ;
Bethwaite, P ;
Tie, A ;
Wilson, I .
GASTROENTEROLOGY, 2002, 122 (07) :1778-1783
[9]   Body mass index and gastroesophageal reflux disease: A systematic review and meta-analysis [J].
Corley, Douglas A. ;
Kubo, Ai .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (11) :2619-2628
[10]   Obesity is associated with increased risk of gastrointestinal symptoms: A population-based study [J].
Delgado-Aros, S ;
Locke, GR ;
Camilleri, M ;
Talley, NJ ;
Fett, S ;
Zinsmeister, AR ;
Melton, LJ .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (09) :1801-1806