5-(Dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide as a novel bifunctional antitumor agent and two-photon induced bio-imaging probe

被引:22
作者
Chui, C. -H. [1 ,5 ]
Wang, Q. [2 ,3 ]
Chow, W. -C. [2 ,3 ]
Yuen, C. W. M. [1 ]
Wong, K. -L. [2 ,3 ]
Kwok, W. -M. [4 ]
Cheng, G. Y. -M. [5 ]
Wong, R. S. -M. [5 ]
Tong, S. -W. [5 ]
Chan, K. -W. [5 ]
Lau, F. -Y. [5 ]
Lai, P. B. -S. [6 ]
Lam, K. -H. [1 ,4 ]
Fabbri, E. [7 ]
Tao, X. -M. [1 ]
Gambari, R. [7 ]
Wong, W. -Y. [2 ,3 ]
机构
[1] Hong Kong Polytech Univ, Inst Text & Clothing, Hong Kong, Hong Kong, Peoples R China
[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
[3] Hong Kong Baptist Univ, Ctr Adv Luminescence Mat, Kowloon Tong, Hong Kong, Peoples R China
[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
[6] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[7] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy
关键词
PHOTOPHYSICAL PROPERTIES; FLUORESCENT SENSOR; METAL-COMPLEXES; IN-VIVO; DANSYL; DENDRIMERS; MICROSCOPY; EMISSION; ACID;
D O I
10.1039/b926908h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel compound, (5-(dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide), was prepared and characterized; it shows dual functional roles as an effective antitumor and a two-photon induced bio-imaging agent.
引用
收藏
页码:3538 / 3540
页数:3
相关论文
共 29 条
[1]   Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions [J].
Aarts, M ;
Liu, YT ;
Liu, LD ;
Besshoh, S ;
Arundine, M ;
Gurd, JW ;
Wang, YT ;
Salter, MW ;
Tymianski, M .
SCIENCE, 2002, 298 (5594) :846-850
[2]   Effect of protons and metal ions on the fluorescence properties of a polylysin dendrimer containing twenty four dansyl units [J].
Balzani, V ;
Ceroni, P ;
Gestermann, S ;
Gorka, M ;
Kauffmann, C ;
Vögtle, F .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2000, (21) :3765-3771
[3]   Designing dendrimers based on transition metal complexes. Light-harvesting properties and predetermined redox patterns [J].
Balzani, V ;
Campagna, S ;
Denti, G ;
Juris, A ;
Serroni, S ;
Venturi, M .
ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (01) :26-34
[4]   Dendrimers as fluorescent sensors with signal amplification [J].
Balzani, V ;
Ceroni, P ;
Gestermann, S ;
Kauffmann, C ;
Gorka, M ;
Vögtle, F .
CHEMICAL COMMUNICATIONS, 2000, (10) :853-854
[5]   Recent developments in transition metal ion detection by luminescent chemosensors [J].
Bargossi, C ;
Fiorini, MC ;
Montalti, M ;
Prodi, L ;
Zaccheroni, N .
COORDINATION CHEMISTRY REVIEWS, 2000, 208 :17-32
[6]   Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib [J].
Berkers, CR ;
Verdoes, M ;
Lichtman, E ;
Fiebiger, E ;
Kessler, BM ;
Anderson, KC ;
Ploegh, HL ;
Ovaa, H ;
Galardy, PJ .
NATURE METHODS, 2005, 2 (05) :357-362
[7]   A new pyridine-based 12-membered macrocycle functionalised with different fluorescent subunits;: coordination chemistry towards CuII, ZnII, CdII, HgII, and PbII [J].
Blake, AJ ;
Bencini, A ;
Caltagirone, C ;
De Filippo, G ;
Dolci, LS ;
Garau, A ;
Isaia, F ;
Lippolis, V ;
Mariani, P ;
Prodi, L ;
Montalti, M ;
Zaccheroni, N ;
Wilson, C .
DALTON TRANSACTIONS, 2004, (17) :2771-2779
[8]   Synthesis and photophysical properties of fluorescent derivatives of methylmercury [J].
Bolletta, F ;
Fabbri, D ;
Lombardo, M ;
Prodi, L ;
Trombini, C ;
Zaccheroni, N .
ORGANOMETALLICS, 1996, 15 (09) :2415-2417
[9]  
Botchway SW, 2008, P NATL ACAD SCI USA, V105, P16071, DOI 10.1073/pnas.0804071105
[10]   Dendrimers functionalized with a single fluorescent dansyl group attached "off center": Synthesis and photophysical studies [J].
Cardona, CM ;
Alvarez, J ;
Kaifer, AE ;
McCarley, TD ;
Pandey, S ;
Baker, GA ;
Bonzagni, NJ ;
Bright, FV .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (26) :6139-6144