Effect of interferon-α on tyrosine hydroxylase and catecholamine levels in the brain of rats

被引：32

作者：

Kumai, T ^{[1
]}

Tateishi, T ^{[1
]}

Tanaka, M ^{[1
]}

Watanabe, M ^{[1
]}

Shimizu, H ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Dept Pharmacol, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

来源：

LIFE SCIENCES | 2000年 / 67卷 / 06期

关键词：

interferon; tyrosine hydroxylase; catecholamine; brain; depression;

D O I：

10.1016/S0024-3205(00)00660-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the effect of interferon on tyrosine hydroxylase (TH) and catecholamine levels in the brains of 12-week-old male Wistar rats. Interferon-alpha (300,000 IU/kg/day, s.c.) was administered to rats for 7 days. Locomotor activity of interferon-alpha-treated rats was significantly lower than that of control rats. Norepinephrine and dopamine levels and TH activities in the cerebral cortex, hypothalamus and medulla oblongata of interferon-alpha-treated rats were significantly higher than those of control rats. Norepinephrine and dopamine levels and TH activities in the thalamus and hippocampus were not different between interferon-alpha treated and control rats. These results suggest that interferon-alpha-induced depression may be related to change in the catecholamine synthetic pathway in the central nervous system. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：663 / 669

页数：7

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