Novel antiproliferative falcarindiol furanocoumarin ethers from the root of Angelica japonica

被引：41

作者：

Furumi, K

Fujioka, T

Fujii, H

Okabe, H

Nakano, Y

Matsunaga, H

Katano, M

Mori, M

Mihashi, K

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 81480, Japan

[2] Saga Med Sch, Fac Hosp Pharm, Saga 849, Japan

[3] Saga Med Sch, Dept Surg, Saga 849, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10193-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel antiproliferative furanocoumarin ethers of falcarindiol, named japoangelols A (8.5), B (7.2), C (7.4), and D (8.4), were isolated from the root of Angelica japonica together with panaxynol (0.3), falcarindiol (3.2), (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2.2), and 8-acetoxyfalcarinol (3.2). Structures were established from the spectroscopic evidence, and the inhibitory activities (ED50, mu g/ml, shown in the parentheses) were evaluated using the MTT assay. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：93 / 96

页数：4