Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis

被引：43

作者：

Caruthers, Shelton D. ^{[1
,2
]}

Cyrus, Tillmann ^{[1
]}

Winter, Patrick M. ^{[1
]}

Wickline, Samuel A. ^{[1
]}

Lanza, Gregory M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63130 USA

[2] Philips Med Syst, St Louis, MO USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2009年 / 1卷 / 03期

关键词：

PARTIAL LIQUID VENTILATION; TARGETED FUMAGILLIN NANOPARTICLES; MAGNETIC-RESONANCE; CONTRAST AGENT; DRUG-DELIVERY; ANTIANGIOGENIC THERAPY; ULTRASONIC CONTRAST; IN-VIVO; ALPHA(V)BETA(3) INTEGRIN; TEMPERATURE-DEPENDENCE;

D O I：

10.1002/wnan.9

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Complementary developments in nanotechnology, genomics, proteomics, molecular biology and imaging offer the potential for early, accurate diagnosis. Molecularly-targeted diagnostic imaging agents will allow noninvasive phenotypic characterization of pathologies and, therefore, tailored treatment close to the onset. For atherosclerosis, this includes anti-angiogenic therapy with specifically-targeted drug delivery systems to arrest the development of plaques before they impinge upon the lumen. Additionally, monitoring the application and effects of this targeted therapy in a serial fashion will be important. This review covers the specific application of alpha(v)beta(3)-targeted anti-angiogenic perfluorocarbon nanopartides in (1) the detection of molecular markers for atherosclerosis, (2) the immediate verification of drug delivery with image-based prediction of therapy outcomes, and (3) the serial, noninvasive observation of therapeutic efficacy.(C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 1 311-323

引用

页码：311 / 323

页数：13

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