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SOCS proteins, cytokine signalling and immune regulation

被引：1270
作者：
Yoshimura, Akihiko
Naka, Tetsuji
Kubo, Masato
机构：
[1] Kyushu Univ, Med Inst Bioregulat, Div Mol & Cellular Immunol, Higashi Ku, Fukuoka 8128582, Japan
[2] Natl Inst Biomed Innovat, Lab Immune Signal, Ibaraki, Osaka 5670085, Japan
[3] RIKEN Yokohama Inst, Lab Signal Network, Res Ctr Allergy & Immunol, Yokohama, Kanagawa 2300045, Japan
来源：
NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 06期
关键词：
D O I：
10.1038/nri2093
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling pathways. Studies have shown that SOCS proteins are key physiological regulators of both innate and adaptive immunity. These molecules positively and negatively regulate macrophage and dendritic-cell activation and are essential for T-cell development and differentiation. Evidence is also emerging of the involvement of SOCS proteins in diseases of the immune system. In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function.
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页码：454 / 465
页数：12
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