CD4+CD25+ suppressor T cells:: More questions than answers

被引:1745
作者
Shevach, EM [1 ]
机构
[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nri821
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Several mechanisms control discrimination between self and non-self, including the thymic deletion of autoreactive T cells and the induction of anergy in the periphery. In addition to these passive mechanisms, evidence has accumulated for the active suppression of autoreactivity by a population of regulatory or suppressor T cells that co-express CD4 and CD25 (the interleukin-2 receptor alpha-chain). CD4(+)CD25(+) T cells are powerful inhibitors of T-cell activation both in vivo and in vitro. The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
引用
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页码:389 / 400
页数:12
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