Electrochemical detection of phenolic compounds using cylindrical carbon-ink electrodes and microchip capillary electrophoresis

被引:40
作者
Ding, Yongsheng [1 ]
Ayon, Arturo [1 ]
Garcia, Carlos D. [1 ]
机构
[1] Univ Texas, Dept Chem, San Antonio, TX 78249 USA
关键词
phenolic compounds; carbon electrodes; microchip; capillary electrophoresis; electrochemical detection;
D O I
10.1016/j.aca.2006.11.064
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A simple method to fabricate cylindrical carbon electrodes for use in capillary electrophoresis (CE) microchips is described. The electrodes were fabricated using a metallic wire coated with carbon ink. Several experimental variables were studied in order to establish the best conditions to fabricate the electrode. Finally, the electrodes were integrated in a poly(dimethylsiloxane) microchip and used for the analysis of phenolic compounds. Using the optimum conditions, the analysis of a mixture of dopamine, epinephrine, catechol, and 4-aminophenol was achieved in less than 240 s, showing good linear responses (R-2 = 0.999) in the 0.1-190 mu M range, and limits of detection (without the use of stacking or a decoupler) of 140 and 105 nM for dopamine and epinephrine, respectively. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:244 / 251
页数:8
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