Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

被引：470

作者：

Qi, Hongzhao ^{[1
]}

Liu, Chaoyong ^{[4
,5
]}

Long, Lixia ^{[1
]}

Ren, Yu ^{[2
]}

Zhang, Shanshan ^{[1
]}

Chang, Xiaodan ^{[1
]}

Qian, Xiaomin ^{[1
]}

Jia, Huanhuan ^{[2
]}

Zhao, Jin ^{[1
]}

Sun, Jinjin ^{[3
]}

Hou, Xin ^{[1
]}

Yuan, Xubo ^{[1
]}

Kang, Chunsheng ^{[4
,5
]}

机构：

[1] Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300072, Peoples R China

[2] Tianjin Med Univ, Tianjin Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[3] Tianjin Med Univ, Hosp 2, Dept Surg, Tianjin 300211, Peoples R China

[4] Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Tianjin Neurol Inst,Lab Neurooncol, Tianjin 300052, Peoples R China

[5] Minist Educ & Tianjin Municipal Govt, Key Lab Neurotrauma Variat & Regenerat, Tianjin 300052, Peoples R China

来源：

ACS NANO | 2016年 / 10卷 / 03期

基金：

国家高技术研究发展计划(863计划);

关键词：

exosome; superparamagnetic nanoparticle clusters; scalable separation; drug delivery; cancer targeting; DRUG-DELIVERY; STEM-CELLS; NANOPARTICLES; FLOW; POLYSACCHARIDES; QUANTIFICATION; MICROVESICLES; TRANSFERRIN; PLATFORMS; RELEASE;

D O I：

10.1021/acsnano.5b06939

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nano particle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.

引用

页码：3323 / 3333

页数：11

共 36 条

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