The T cell repertoire in infection and vaccination: implications for control of persistent viruses

被引：56

作者：

Davenport, Miles P.

Price, David A.

McMichael, Andrew J. ^{[1
]}

机构：

[1] Univ New S Wales, Prince Wales Hosp, Dept Haematol, Kensington, NSW 2052, Australia

[2] Univ New S Wales, Ctr Vasc Res, Kensington, NSW 2052, Australia

[3] Natl Inst Allergy & Infect Dis, Human Immunol Sect, NIH, Bethesda, MD 20892 USA

[4] John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford OX3 9DS, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most currently available vaccines target acute infectious agents such as polio, smallpox and influenza virus. The development of vaccines to persistent infectious agents has proven much more difficult. Although it is possible to generate T cell responses to such viruses, these responses are currently unable to prevent the establishment of infection, and immune control may be lost during the chronic phase. Recent advances have increased our understanding of the interactions between persistent viruses and the available T cell repertoire, and will guide approaches to the generation and maintenance of an 'ideal' T cell response.

引用

页码：294 / 300

页数：7

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