Microheater based on magnetic nanoparticle embedded PDMS

被引：59

作者：

Kim, Jeong Ah ^{[1
]}

Lee, Seung Hwan ^{[1
]}

Park, Hongsuk ^{[2
]}

Kim, Jong Hyo ^{[3
]}

Park, Tai Hyun ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[2] Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 151744, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 110744, South Korea

来源：

NANOTECHNOLOGY | 2010年 / 21卷 / 16期

关键词：

PCR; HYPERTHERMIA; SYSTEM; CHIP; DEPENDENCE; PARTICLES; DEVICE;

D O I：

10.1088/0957-4484/21/16/165102

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A microheater was established by embedding magnetic nanoparticles into PDMS (MNP-PDMS). MNP-PDMS generated heat under an AC magnetic field and the temperature was controlled by varying the magnetic particle content and the magnetic field intensity. In this study, the MNP-PDMS chip was demonstrated to amplify the target DNA (732 bp) with >90% efficiency compared to the conventional PCR thermocycler, and exhibited good performance in regards to temperature control. This system holds great promise for reliably controlling the temperature of thermal processes on an integrated microchip platform for biochemical applications.

引用

页数：7

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