Cell death induced by MPTP, a substrate for monoamine oxidase B

被引:47
作者
Nicotra, A
Parvez, SH
机构
[1] Univ Rome 1, Dipartimento Biol Anim & Uomo, I-00185 Rome, Italy
[2] Inst Alfred Fessard Neurosci, CNRS UPR 2212, F-91190 Gif Sur Yvette, France
关键词
cell death; monoamine oxidase B; dopaminergic neurons;
D O I
10.1016/S0300-483X(00)00311-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
MPTP is known to cause PD symptoms in primates and in rodents. In order to exert its neurotoxicity MPTP must be converted by monoamine oxidase B into MPP+ which is the true toxic agent. MPP+ is taken up by the dopaminergic neurons of the substantia nigra in which it induces cell death. The present work reviews and discusses papers in which specific methods were used to determine whether cell death induced by MPTP/MPP+ should be considered as apoptosis or necrosis. These two cell death modes may be distinguished using morphological and biochemical criteria. The effect of MPTP/MPP+ was studied in vitro and in vivo. The results show that no univocal answer is possible. The most widespread interpretation is that MPTP/MPP+ causes apoptosis when its neurotoxic effect is only sligh and necrosis when it is stronger. Similar considerations may be made also concerning the type of cell death occurring in the dopaminergic neurons in the substantia nigra of PD patients. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.
引用
收藏
页码:157 / 166
页数:10
相关论文
共 56 条
[1]  
Anglade P, 1997, HISTOL HISTOPATHOL, V12, P25
[2]   TRIBUTYLTIN STIMULATES APOPTOSIS IN RAT THYMOCYTES [J].
AW, TY ;
NICOTERA, P ;
MANZO, L ;
ORRENIUS, S .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 283 (01) :46-50
[3]   Oxidative damage and tyrosine nitration from peroxynitrite [J].
Beckman, JS .
CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (05) :836-844
[4]  
BELLOMO G, 1992, CANCER RES, V52, P1342
[5]   APOPTOSIS OR PROGRAMMED CELL-DEATH [J].
BOWEN, ID .
CELL BIOLOGY INTERNATIONAL, 1993, 17 (04) :365-380
[6]  
Burke RE, 1998, MOVEMENT DISORD, V13, P17
[7]  
BURNS RB, 1983, PRIMATE MODEL PARKIN
[8]   IMMORTALIZATION OF EMBRYONIC MESENCEPHALIC DOPAMINERGIC-NEURONS BY SOMATIC-CELL FUSION [J].
CHOI, HK ;
WON, LA ;
KONTUR, PJ ;
HAMMOND, DN ;
FOX, AP ;
WAINER, BH ;
HOFFMANN, PC ;
HELLER, A .
BRAIN RESEARCH, 1991, 552 (01) :67-76
[9]  
Choi WS, 1999, J NEUROSCI RES, V57, P86, DOI 10.1002/(SICI)1097-4547(19990701)57:1<86::AID-JNR9>3.3.CO
[10]  
2-5