Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis

被引：149

作者：

Alangaden, GJ

Kreiswirth, BN

Aouad, A

Khetarpal, M

Igno, FR

Moghazeh, SL

Manavathu, EK

Lerner, SA

机构：

[1] Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA

[3] Publ Hlth Res Inst City New York Inc, TB Ctr, New York, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1295

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An A1400G mutation of the ns gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 mu g/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

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页码：1295 / 1297

页数：3

相关论文

共 22 条

[1]

ALANGADEN GJ, 1996, 36 INT C ANT AG CHEM, P58

[2] AMIKACIN IN THE TREATMENT OF PULMONARY TUBERCULOSIS [J].

ALLEN, BW ;

MITCHISON, DA ;

CHAN, YC ;

YEW, WW ;

ALLAN, WGL ;

GIRLING, DJ .

TUBERCLE, 1983, 64 (02) :111-118

[3] SITES OF ACTION OF 2 RIBOSOMAL-RNA METHYLASES RESPONSIBLE FOR RESISTANCE TO AMINOGLYCOSIDES [J].

BEAUCLERK, AAD ;

CUNDLIFFE, E .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 193 (04) :661-671

[4] Characterization of streptomycin resistance mechanisms among Mycobacterium tuberculosis isolates from patients in New York City [J].

Cooksey, RC ;

Morlock, GP ;

McQueen, A ;

Glickman, SE ;

Crawford, JT .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (05) :1186-1188

[5] MUTATIONS IN 16S RIBOSOMAL-RNA DISRUPT ANTIBIOTIC - RNA INTERACTIONS [J].

DESTASIO, EA ;

MOAZED, D ;

NOLLER, HF ;

DAHLBERG, AE .

EMBO JOURNAL, 1989, 8 (04) :1213-1216

[6] A RIBOSOMAL GENE MUTATION IN STREPTOMYCIN-RESISTANT MYCOBACTERIUM-TUBERCULOSIS ISOLATES [J].

DOUGLASS, J ;

STEYN, LM .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (06) :1505-1506

[7] MOLECULAR-BASIS OF STREPTOMYCIN RESISTANCE IN MYCOBACTERIUM-TUBERCULOSIS - ALTERATIONS OF THE RIBOSOMAL-PROTEIN S12 GENE AND POINT MUTATIONS WITHIN A FUNCTIONAL 16S RIBOSOMAL-RNA PSEUDOKNOT [J].

FINKEN, M ;

KIRSCHNER, P ;

MEIER, A ;

WREDE, A ;

BOTTGER, EC .

MOLECULAR MICROBIOLOGY, 1993, 9 (06) :1239-1246

[8] IMPLICATIONS OF MULTIDRUG-RESISTANCE FOR THE FUTURE OF SHORT-COURSE CHEMOTHERAPY OF TUBERCULOSIS - A MOLECULAR STUDY [J].

HEYM, B ;

HONORE, N ;

TRUFFOTPERNOT, C ;

BANERJEE, A ;

SCHURRA, C ;

JACOBS, WR ;

VANEMBDEN, JD ;

GROSSET, JH ;

COLE, ST .

LANCET, 1994, 344 (8918) :293-298

[9] STREPTOMYCIN RESISTANCE IN MYCOBACTERIA [J].

HONORE, N ;

COLE, ST .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :238-242

[10] THE NUCLEOTIDE-SEQUENCE OF THE PROMOTER, 16S RIBOSOMAL-RNA AND SPACER REGION OF THE RIBOSOMAL-RNA OPERON OF MYCOBACTERIUM-TUBERCULOSIS AND COMPARISON WITH MYCOBACTERIUM-LEPRAE PRECURSOR RIBOSOMAL-RNA [J].

KEMPSELL, KE ;

JI, YE ;

ESTRADA, ICE ;

COLSTON, MJ ;

COX, RA .

JOURNAL OF GENERAL MICROBIOLOGY, 1992, 138 :1717-1727