AQUA: automated quality improvement for multiple sequence alignments

被引：43

作者：

Muller, Jean ^{[2
]}

Creevey, Christopher J. ^{[2
]}

Thompson, Julie D. ^{[1
]}

Arendt, Detlev ^{[2
]}

Bork, Peer ^{[2
,3
]}

机构：

[1] ULP, INSERM, CNRS,Inst Genet & Biol Mol & Cellulaire, Dept Biol & Genom Struct, F-67404 Illkirch Graffenstaden, France

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

[3] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

BIOINFORMATICS | 2010年 / 26卷 / 02期

关键词：

INFORMATION; WORKBENCH;

D O I：

10.1093/bioinformatics/btp651

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple sequence alignment (MSA) is a central tool in most modern biology studies. However, despite generations of valuable tools, human experts are still able to improve automatically generated MSAs. In an effort to automatically identify the most reliable MSA for a given protein family, we propose a very simple protocol, named AQUA for 'Automated quality improvement for multiple sequence alignments'. Our current implementation relies on two alignment programs (MUSCLE and MAFFT), one refinement program (RASCAL) and one assessment program (NORMD), but other programs could be incorporated at any of the three steps.

引用

页码：263 / 265

页数：3

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