A structured ancestral population for the evolution of modern humans

被引:55
作者
Harding, RM
McVean, G
机构
[1] Univ Oxford, Biol Anthropol Unit, Oxford OX1 3TG, England
[2] Univ Oxford, Dept Stat, Oxford OX1 3TG, England
关键词
D O I
10.1016/j.gde.2004.08.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The view that modern humans evolved through a bottleneck from a single founding group of archaic Homo is being challenged by new analyses of contemporary genetic variation. A wide range of middle to late Pleistocene ages for gene genealogies and evidence for early population structures point to a diverse and scattered ancestry associated with a metapopulation history of local extinctions, re-colonization and admixture. A different balance of the same processes has shaped chimpanzee diversity.
引用
收藏
页码:667 / 674
页数:8
相关论文
共 83 条
[1]   Interrogating a high-density SNP map for signatures of natural selection [J].
Akey, JM ;
Zhang, G ;
Zhang, K ;
Jin, L ;
Shriver, MD .
GENOME RESEARCH, 2002, 12 (12) :1805-1814
[2]   Modern humans - What made humans modern? [J].
Balter, M .
SCIENCE, 2002, 295 (5558) :1219-+
[3]   Recent developments in genetic data analysis: what can they tell us about human demographic history? [J].
Beaumont, MA .
HEREDITY, 2004, 92 (05) :365-379
[4]   MITOCHONDRIAL-DNA AND HUMAN-EVOLUTION [J].
CANN, RL ;
STONEKING, M ;
WILSON, AC .
NATURE, 1987, 325 (6099) :31-36
[5]   Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans [J].
Caramelli, D ;
Lalueza-Fox, C ;
Vernesi, C ;
Lari, M ;
Casoli, A ;
Mallegni, F ;
Chiarelli, B ;
Dupanloup, I ;
Bertranpetit, J ;
Barbujani, G ;
Bertorelle, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) :6593-6597
[6]   The application of molecular genetic approaches to the study of human evolution [J].
Cavalli-Sforza, LL ;
Feldman, MW .
NATURE GENETICS, 2003, 33 :266-275
[7]   Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees [J].
Chen, FC ;
Li, WH .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (02) :444-456
[8]   Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios [J].
Clark, AG ;
Glanowski, S ;
Nielsen, R ;
Thomas, PD ;
Kejariwal, A ;
Todd, MA ;
Tanenbaum, DM ;
Civello, D ;
Lu, F ;
Murphy, B ;
Ferriera, S ;
Wang, G ;
Zheng, XG ;
White, TJ ;
Sninsky, JJ ;
Adams, MD ;
Cargill, M .
SCIENCE, 2003, 302 (5652) :1960-1963
[9]   Ancient DNA: Would the real neandertal please stand up? [J].
Cooper, A ;
Drummond, AJ ;
Willerslev, E .
CURRENT BIOLOGY, 2004, 14 (11) :R431-R433
[10]   Growth processes in teeth distinguish modern humans from Homo erectus and earlier hominins [J].
Dean, C ;
Leakey, MG ;
Reid, D ;
Schrenk, F ;
Schwartz, GT ;
Stringer, C ;
Walker, A .
NATURE, 2001, 414 (6864) :628-631