DNA-Mediated enantioselective carbon-fluorine bond formation

被引：117

作者：

Shibata, Norio ^{[1
]}

Yasui, Hiroyuki ^{[1
]}

Nakamura, Shuichi ^{[1
]}

Toru, Takeshi ^{[1
]}

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Appl Chem, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

SYNLETT | 2007年 / 07期

关键词：

fluorine; DNA; asymmetric catalysis; copper; halogenation;

D O I：

10.1055/s-2007-977429

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective electrophilic fluorination of beta-keto esters with Selectfluor (R) catalyzed by DNA and a nonchiral ligand-Cu(II) complex is presented. The chirality transfer from DNA to the substrate appears to be caused by the intercalation or groove binding of the substrate-ligand-Cu(II) complex to DNA.

引用

页码：1153 / 1157

页数：5

共 69 条

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