Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy

被引：67

作者：

Allen, NJ ^{[1
]}

Káradóttir, R ^{[1
]}

Attwell, D ^{[1
]}

机构：

[1] UCL, Dept Physiol, London WC1E 6BT, England

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 449卷 / 02期

关键词：

GABA; glutamate; neurodegeneration; reversal; transporter;

D O I：

10.1007/s00424-004-1318-x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. This dysfunction can comprise a reversal of transport direction, leading to the release of neurotransmitter into the extracellular space, or an alteration in transporter expression level. This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders.

引用

页码：132 / 142

页数：11

共 102 条

[1]

Agrawal SK, 1997, J NEUROSCI, V17, P1055

[2] Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats [J].