Tyrosine phosphatases in vessel wall signaling

被引：62

作者：

Kappert, K

Peters, KG

Böhmer, FD

Östman, A

机构：

[1] Canc Ctr Karolinska, Dept Pathol & Oncol, Karolinska Inst, S-17176 Stockholm, Sweden

[2] Procter & Gamble Pharmaceut, Mason, OH 45040 USA

[3] Univ Jena, Fac Med, Inst Mol Cell Biol, D-07747 Jena, Germany

来源：

CARDIOVASCULAR RESEARCH | 2005年 / 65卷 / 03期

关键词：

protein tyrosine phosphatase; cardiovascular disease; cell signaling; angiogenesis; antherogenesis;

D O I：

10.1016/j.cardiores.2004.08.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Protein tyrosine phosphatases (PTPs) are critical regulators of cellular processes like migration, proliferation and differentiation that are involved in physiological and pathological vessel wall function. In this review, we summarize the biochemistry of this enzyme family, discuss the present knowledge concerning the identity and involvement of PTPs in vascular cells and in pathways of relevance to cardiovascular diseases. We also briefly introduce ongoing efforts to develop inhibitors of PTPs, and finally point to some opportunities for use of such agents in novel treatment strategies. (C) 2004 European Society of Cardiology. Published by Elsevier B.V.

引用

收藏

页码：587 / 598

页数：12

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