Role of tissue factor in thrombosis in antiphospholipid antibody syndrome

被引：42

作者：

Boles, J. ^{[1
]}

Mackman, N. ^{[1
]}

机构：

[1] Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27599 USA

来源：

LUPUS | 2010年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

antiphospholipid syndrome; thrombosis; coagulation; tissue factor; DIC; ACTIVATED PROTEIN-KINASE; FACTOR MESSENGER-RNA; ENDOTHELIAL-CELL ACTIVATION; DISSEMINATED INTRAVASCULAR COAGULATION; ALLOSTERIC DISULFIDE BOND; FACTOR PATHWAY INHIBITOR; TUMOR-NECROSIS-FACTOR; FACTOR EXPRESSION; IN-VIVO; ANTICARDIOLIPIN ANTIBODIES;

D O I：

10.1177/0961203309360810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of an antiphospholipid antibody (aPL) and the occurrence of at least one associated clinical condition that includes venous thrombosis, arterial thrombosis or pregnancy morbidity. The aPL detected in APS have long been thought to have a direct prothrombotic effect in vivo. However, the pathophysiology underlying their coagulopathic effect has not been defined. Emerging data suggest a role for the procoagulant protein tissue factor (TF). In this review we provide an overview of TF, describe mouse models used in the evaluation of the role of TF in thrombosis, as well as summarize recent work on TF and APS. Lupus (2010) 19, 370-378.

引用

页码：370 / 378

页数：9

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