Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu

被引：92

作者：

Naito, T

Saito, Y

Yamamoto, J

Nozaki, Y

Tomura, K

Hazama, M

Nakanishi, S

Brenner, S

机构：

[1] Japan Tobacco Inc, Pharmaceut Frontier Res Labs, Kanazawa Ku, Yokohama, Kanagawa 236, Japan

[2] Kyoto Univ, Fac Med, Dept Biol Sci, Sakyo Ku, Kyoto 606, Japan

[3] Inst Mol Sci, Berkeley, CA 94704 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 09期

关键词：

D O I：

10.1073/pnas.95.9.5178

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By a combination of PCR with degenerate primers and Iom stringency probing, we have isolated a large family of genes related to the Ca2+-sensing receptor from the genome of Fugu rubripes. One of the genes (type I) is the Fugu homologue of the Ca2+-sensing receptor. The remaining genes can be divided into five classes (type II-VI) on the base's of gene structure. In several types, the genes occur in clusters as tandem arrays. These genes appear to be the homologues of the vomeronasal pheromone receptors recently described in rodents. The Fuga genes are expressed in the tissues of the nose, suggesting that they may have a similar physiological role.

引用

页码：5178 / 5181

页数：4

共 9 条

[1] A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].