Stereocontrolled synthesis of chiral secondary (alpha-methylene-beta-substituted)-gamma-lactams by addition of beta-functional crotylzinc reagents to chiral imines.

被引：51

作者：

Nyzam, V ^{[1
]}

Belaud, C ^{[1
]}

Zammattio, F ^{[1
]}

Villieras, J ^{[1
]}

机构：

[1] FAC SCI & TECH,ORGAN SYNTH LAB,CNRS,URA 475,F-44072 NANTES 03,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/0957-4166(96)00219-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Stereocontrolled addition of functionalised crotylzinc reagents to chiral imines derived either from N-alpha-aminoesters or N-beta-aminoalcohols furnished secondary alpha-methylene-beta-substituted-gamma-lactams in excellent diastereoisomeric excess (de approximate to 92-100%). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1835 / 1843

页数：9

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