Presence of the pineal hormone melatonin in rat cochlea: its variations with lighting conditions

被引：23

作者：

Lopez-Gonzalez, MA

Guerrero, JM

Delgado, F

机构：

[1] Univ Virgen Rocio, Hosp Infantil, Unidad ORL Pediatr, Seville 41013, Spain

[2] Virgen Macarena Univ Hosp, Dept Med Biochem & Mol Biol, Seville, Spain

来源：

NEUROSCIENCE LETTERS | 1997年 / 238卷 / 1-2期

关键词：

pineal gland; melatonin; circadian cycle; autoimmunity; inner ear;

D O I：

10.1016/S0304-3940(97)00844-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Within the normal inner ear, there are elements that belong to the immune system. Different inner ear disorders can be explained by autoimmune mechanisms, affecting both humoral and cellular immunity. Melatonin, the principal hormone of the pineal gland, modulates the immune system and extensively participates in the autoimmune processes related to type II collagen. Therefore, we have studied the presence of melatonin in rat cochlea, proving that its concentrations change depending on lighting conditions. Rats show high levels when confined to darkness and low levels when subject to continuous light exposure. The results correlate with the concentration of melatonin in peripheral circulation. Further experimental and clinical studies are necessary to clarify the role and the possible therapeutic applications of melatonin. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：81 / 83

页数：3

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