β-dimethylphenylsilylethyl esters:: a linker for solid-phase chemistry

被引:15
作者
Alonso, C [1 ]
Nantz, MH [1 ]
Kurth, MJ [1 ]
机构
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(00)00909-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Preparation of a beta-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO-->RCH=NOH-->isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:5617 / 5622
页数:6
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