Ineffectiveness of oral coenzyme Q10 supplementation in 3-methylglutaconic aciduria, type 3

被引：7

作者：

Costeff, H

Apter, N

Elpeleg, ON ^{[1
]}

Prialnic, M

Bohles, HJ

机构：

[1] Shaare Zedek Med Ctr, Metab Dis Unit, Jerusalem, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Loewenstein Hosp, Roanana, Israel

[4] Golda Med Ctr, Dept Ophthalmol, Petah Tiqwa, Israel

[5] Johann Wolfgang Goethe Univ Clin, Dept Pediat, Frankfurt, Germany

来源：

BRAIN & DEVELOPMENT | 1998年 / 20卷 / 01期

关键词：

3-methylglutaconic aciduria type 3; Iraqi Jewish optic atrophy syndrome; optic atrophy plus; coenzyme Q10;

D O I：

10.1016/S0387-7604(97)00096-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Coenzyme Q10 was administered under placebo controlled blinded crossover conditions to six subjects suffering from type 3 3-methylglutaconic aciduria ('optic atrophy plus'), following a report of benefit. Despite attainment of high plasma levels of coenzyme Q10, no clinical benefit was observed and there was no diminution of urinary excretion of 3-methylglutaconic acid. (C) 1998 Elsevier Science B.V.

引用

页码：33 / 35

页数：3

共 9 条

[1] 3-METHYLGLUTACONIC ACIDURIA - 10 NEW CASES WITH A POSSIBLE NEW PHENOTYPE [J].