Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts

被引：18

作者：

Hüffmeier, U

Traupe, H

Burkhardt, H

Schürmeier-Horst, F

Lascorz, J

Böhm, B

Lohmann, J

Ständer, M

Wendler, J

Kelsch, R

Baumann, C

Küster, W

Wienker, TF

Reis, A

机构：

[1] Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany

[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany

[3] Univ Erlangen Nuremberg, Dept Internal Med Rheumatol 3, Nurnberg, Germany

[4] Psoriasis Rehabil Hosp, Bad Bentheim, Germany

[5] Rheumatol Schwerpunktpraxis, Erlangen, Germany

[6] Univ Clin Munster, Inst Transfus Med, Munster, Germany

[7] TOMESA Clin, Bad Salzschlirf, Germany

[8] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-5300 Bonn, Germany

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2005年 / 124卷 / 01期

关键词：

HCR; psoriasis; psoriatic arthritis; PSORS1; stratification;

D O I：

10.1111/j.0022-202X.2004.23571.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.

引用

页码：107 / 110

页数：4

共 17 条

[1] Psoriasis susceptibility locus on 18p revealed by genome scan in Finnish families not associated with PSORS1 [J].