Wnt Signaling and the Polarity of the Primary Body Axis

被引：407

作者：

Petersen, Christian P. ^{[1
]}

Reddien, Peter W. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

CELL | 2009年 / 139卷 / 06期

关键词：

NUCLEAR BETA-CATENIN; SEA-URCHIN EMBRYO; C-ELEGANS EMBRYOS; ASYMMETRIC CELL DIVISIONS; PLANARIAN REGENERATION; SPEMANN ORGANIZER; WNT/BETA-CATENIN; MOUSE EMBRYO; DORSOVENTRAL AXIS; XENOPUS EMBRYOS;

D O I：

10.1016/j.cell.2009.11.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through beta-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals.

引用

页码：1056 / 1068

页数：13

共 104 条

[1] Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning [J].

Adamska, Maja ;

Degnan, Sandie M. ;

Green, Kathryn M. ;

Adamski, Marcin ;

Craigie, Alina ;

Larroux, Claire ;

Degnan, Bernard M. .

PLOS ONE, 2007, 2 (10)

[2] Smed-Evi/Wntless is required for β-catenin-dependent and -independent processes during planarian regeneration [J].

Adell, Teresa ;

Salo, Emili ;

Boutros, Michael ;

Bartscherer, Kerstin .

DEVELOPMENT, 2009, 136 (06) :905-910

[3] The new animal phylogeny: Reliability and implications [J].

Adoutte, A ;

Balavoine, G ;

Lartillot, N ;

Lespinet, O ;

Prud'homme, B ;

de Rosa, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4453-4456

[4] The molecular nature of the zebrafish tail organizer [J].

Agathon, A ;

Thisse, C ;

Thisse, B .

NATURE, 2003, 424 (6947) :448-452

[5] A β-catenin gradient links the clock and wavefront systems in mouse embryo segmentation [J].

Aulehla, Alexander ;

Wiegraebe, Winfried ;

Baubet, Valerie ;

Wahl, Matthias B. ;

Deng, Chuxia ;

Taketo, Makoto ;

Lewandoski, Mark ;

Pourquie, Olivier .

NATURE CELL BIOLOGY, 2008, 10 (02) :186-U56

[6] Multiple Wnt Genes Are Required for Segmentation in the Short-Germ Embryo of Tribolium castaneum [J].

Bolognesi, Renata ;

Farzana, Laila ;

Fischer, Tamara D. ;

Brown, Susan J. .

CURRENT BIOLOGY, 2008, 18 (20) :1624-1629

[7] Tribolium Wnts:: evidence for a larger repertoire in insects with overlapping expression patterns that suggest multiple redundant functions in embryogenesis [J].

Bolognesi, Renata ;

Beermann, Anke ;

Farzana, Laila ;

Wittkopp, Nadine ;

Lutz, Rebekka ;

Balavoine, Guillaume ;

Brown, Susan J. ;

Schroeder, Reinhard .

DEVELOPMENT GENES AND EVOLUTION, 2008, 218 (3-4) :193-202

[8] Formation of the head organizer in hydra involves the canonical Wnt pathway [J].

Broun, M ;

Gee, L ;

Reinhardt, B ;

Bode, HR .

DEVELOPMENT, 2005, 132 (12) :2907-2916

[9] INTERACTIONS BETWEEN XWNT-8 AND SPEMANN ORGANIZER SIGNALING PATHWAYS GENERATE DORSOVENTRAL PATTERN IN THE EMBRYONIC MESODERM OF XENOPUS [J].

CHRISTIAN, JL ;

MOON, RT .

GENES & DEVELOPMENT, 1993, 7 (01) :13-28

[10] Wnt gradient formation requires retromer function in Wnt-producing cells [J].

Coudreuse, DYM ;

Roël, G ;

Betist, MC ;

Destrée, O ;

Korswagen, HC .

SCIENCE, 2006, 312 (5775) :921-924

← 1 2 3 4 5 6 7 8 9 10 →