MicroRNAs in cancer - from research to therapy

被引：197

作者：

Cho, William C. S. ^{[1
]}

机构：

[1] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1805卷 / 02期

关键词：

Cancer; Locked nucleic acid; MicroRNA; Target gene; Therapy; CELL-CYCLE REGULATION; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; IN-VITRO; MESENCHYMAL TRANSITION; MIR-21; EXPRESSION; DOWN-REGULATION; UP-REGULATION; PROLIFERATION;

D O I：

10.1016/j.bbcan.2009.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) regulate target gene expression through translation repression or mRNA degradation. These non-coding RNAs are emerging as important modulators in cellular pathways, and they appear to play a key role in tumorigenesis. With increasing understanding of the miRNA target genes and the cellular behaviors influenced by them, modulating the miRNA activities may provide exciting opportunities for cancer therapy. Here the latest findings of which genes are targeted by each miRNA are reviewed, with particular emphasis on the deciphering of their possible mechanisms and the potential of miRNA-based cancer therapeutics. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：209 / 217

页数：9

共 69 条

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