Transcriptional regulation of Th1/Th2 polarization

被引：403

作者：

Rengarajan, J ^{[1
]}

Szabo, SJ ^{[1
]}

Glimcher, LH ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(00)01712-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The two polarized T helper (Th) subsets Th1 and Th2 are identified by their signature cytokines, interferon gamma (IFN-gamma) and interleukin 4 (IL-4) respectively. Understanding the transcriptional regulation of cytokine expression is therefore critical for elucidating the process of Th cell differentiation. Ubiquitous and tissue-specific transcription factors, as well as chromatin remodeling of genomic loci have been implicated in IL-4 and IFN-gamma regulation. We propose a model of Th1/Th2 polarization based on the balance between Th1- and Th2-specific transcription factors.

引用

页码：479 / 483

页数：5

共 39 条

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