Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients

被引:56
作者
Harjutsalo, V
Podar, T
Tuomilehto, J
机构
[1] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet & Genet Epidemiol Unit, FIN-00300 Helsinki, Finland
[2] Endocrinol Ctr, Tartu, Estonia
[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[4] S Ostrobotnia Cent Hosp, Seinajoki, Finland
关键词
D O I
10.2337/diabetes.54.2.563
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aims of our analysis were to obtain the empirical risk estimates for type 1 diabetes in the siblings of a Finnish population-based cohort of childhood-onset diabetic patients and search for demographic and other factors predicting the risk of type 1 diabetes in siblings. We defined the diabetes status of all siblings of all probands who are included in the nationwide register of Finnish cases for whom type 1 diabetes was diagnosed before age 18 years between 1965 and 1979. Siblings' diabetes status was ascertained by a record search of nationwide registries through 2001, and the type of diabetes and date of its manifestation were obtained from medical records. The total number of person-years during the follow-up was 405,685. Of the 10,168 siblings at risk, 647 (6.4%) had been diagnosed with type 1 diabetes by 2001. The cumulative incidence of type 1 diabetes by ages 10, 20, 30, 40, and 50 years in all siblings was 1.5, 4.1, 5.5, 6.4, and 6.9%, respectively. A young age at diagnosis in the index case, paternal young-onset diabetes, male sex, and older parental age at delivery considerably increased the risk of type 1 diabetes for siblings. This large prospective family study of type 1 diabetes in siblings of childhood-onset diabetic patients provides reliable empirical estimates for the sibling recurrence risk.
引用
收藏
页码:563 / 569
页数:7
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