PCNA, the maestro of the replication fork

被引：1401

作者：

Moldovan, George-Lucian

Pfander, Boris

Jentsch, Stefan

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA

[3] Canc Res UK, Clare Hall Labs, S Mimms EH6 3LD, Herts, England

来源：

CELL | 2007年 / 129卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

引用

页码：665 / 679

页数：15

共 105 条

[1] A role for PCNA ubiquitination in immunoglobulin hypermutation
Arakawa, Hiroshi
Moldovan, George-Lucian
Saribasak, Huseyin
Saribasak, Nesibe Nur
Jentsch, Stefan
Buerstedde, Jean-Marie
[J]. PLOS BIOLOGY, 2006, 4 (11): : 1947 - 1956
[2] PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
Arias, EE
Walter, JC
[J]. NATURE CELL BIOLOGY, 2006, 8 (01) : 84 - U33
[3] Interaction of CR6 (GADD45γ) with proliferating cell nuclear antigen impedes negative growth control
Azam, N
Vairapandi, M
Zhang, W
Hoffman, B
Liebermann, DA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2766 - 2774
[4] L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes
Banks, Damon
Wu, Min
Higa, Leigh Ann
Gavrilova, Nadia
Quan, Junmin
Ye, Tao
Kobayashi, Ryuji
Sun, Hong
Zhang, Hui
[J]. CELL CYCLE, 2006, 5 (15) : 1719 - 1729
[5] Regulation of alternative replication bypass pathways at stalled replication forks and its effects on genome stability: a yeast model
Barbour, L
Xiao, W
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 532 (1-2) : 137 - 155
[6] DNA replication in eukaryotic cells
Bell, SP
Dutta, A
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 : 333 - 374
[7] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
Bienko, M
Green, CM
Crosetto, N
Rudolf, F
Zapart, G
Coull, B
Kannouche, P
Wider, G
Peter, M
Lehmann, AR
Hofmann, K
Dikic, I
[J]. SCIENCE, 2005, 310 (5755) : 1821 - 1824
[8] DNA methylation patterns and epigenetic memory
Bird, A
[J]. GENES & DEVELOPMENT, 2002, 16 (01) : 6 - 21
[9] Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex
Bowman, GD
O'Donnell, M
Kuriyan, J
[J]. NATURE, 2004, 429 (6993) : 724 - 730
[10] Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1
Bruning, JB
Shamoo, Y
[J]. STRUCTURE, 2004, 12 (12) : 2209 - 2219

← 1 2 3 4 5 6 7 8 9 10 →