Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells

被引：96

作者：

Lee, HY ^{[1
]}

Murata, J ^{[1
]}

Clair, T ^{[1
]}

Polymeropoulos, MH ^{[1
]}

Torres, R ^{[1
]}

Manrow, RE ^{[1
]}

Liotta, LA ^{[1
]}

Stracke, ML ^{[1
]}

机构：

[1] NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 218卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/bbrc.1996.0127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autotaxin. a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1. The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-1. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24. Northern blot analysis of relative mRNA from multiple human tissues revealed that autoraxin mRNA steady state expression is most abundant in brain, placenta, ovary, and small intestine. (C) 1996 Academic Press, Inc.

引用

页码：714 / 719

页数：6

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