Inflammatory biomarkers and coronary heart disease: from bench to bedside and back

被引：44

作者：

Biasillo, Gina ^{[1
]}

Leo, Milena ^{[1
]}

Della Bona, Roberta ^{[1
]}

Biasucci, Luigi Marzio ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy

来源：

INTERNAL AND EMERGENCY MEDICINE | 2010年 / 5卷 / 03期

关键词：

Inflammation; Biomarkers; Atherosclerosis; Coronary heart disease; C-REACTIVE PROTEIN; SOLUBLE CD40 LIGAND; ACUTE MYOCARDIAL-INFARCTION; SERUM-AMYLOID-A; APPARENTLY HEALTHY-MEN; UNSTABLE ANGINA; ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; PLASMA-PROTEIN; PROGNOSTIC VALUE;

D O I：

10.1007/s11739-010-0361-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation plays a pivotal role in all stages of atherosclerosis from endothelial dysfunction and plaque formation to plaque destabilization and disruption. Inflammatory biomarkers, originally studied to better understand the pathophysiology of atherosclerosis, have generated increasing interest among clinicians, because of their utility in the challenging problems of diagnosis and risk assessment of patients with suspected or proved coronary heart disease. Moreover, in fascinating perspective, they could be used as therapeutic target, counteracting initiation, progression, and development of complications of atherosclerosis. In this review, we will provide an overview of the more promising inflammatory biomarkers, focusing on their utility and limitations in the clinical setting.

引用

页码：225 / 233

页数：9

共 50 条

[1] Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina -: Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes [J].

Aukrust, P ;

Müller, F ;

Ueland, T ;

Berget, T ;

Aaser, E ;

Brunsvig, A ;

Solum, NO ;

Forfang, K ;

Froland, SS ;

Gullestad, L .

CIRCULATION, 1999, 100 (06) :614-620

[2] Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase [J].

Baldus, S ;

Rudolph, V ;

Roiss, M ;

Ito, WD ;

Rudolph, TK ;

Eiserich, JP ;

Sydow, K ;

Lau, D ;

Szöcs, K ;

Klinke, A ;

Kubala, L ;

Berglund, L ;

Schrepfer, S ;

Deuse, T ;

Haddad, M ;

Risius, T ;

Klemm, H ;

Reichenspurner, HC ;

Meinertz, T ;

Heitzer, T .

CIRCULATION, 2006, 113 (15) :1871-1878

[3] Pregnancy-associated plasma protein a as a marker of acute coronary syndromes [J].

Bayes-Genis, A ;

Conover, CA ;

Overgaard, MT ;

Bailey, KR ;

Christiansen, M ;

Holmes, DR ;

Virmani, R ;

Oxvig, C ;

Schwartz, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (14) :1022-1029

[4] Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability [J].

Biasucci, LM ;

Liuzzo, G ;

Grillo, RL ;

Caligiuri, G ;

Rebuzzi, AG ;

Buffon, A ;

Summaria, F ;

Ginnetti, F ;

Fadda, G ;

Maseri, A .

CIRCULATION, 1999, 99 (07) :855-860

[5] Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events [J].

Biasucci, LM ;

Liuzzo, G ;

Fantuzzi, G ;

Caligiuri, G ;

Rebuzzi, AG ;

Ginnetti, F ;

Dinarello, CA ;

Maseri, A .

CIRCULATION, 1999, 99 (16) :2079-2084

[6] Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease [J].

Blankenberg, S ;

Rupprecht, HJ ;

Poirier, O ;

Bickel, C ;

Smieja, M ;

Hafner, G ;

Meyer, J ;

Cambien, F ;

Tiret, L .

CIRCULATION, 2003, 107 (12) :1579-1585

[7] Prognostic value of myeloperoxidase in patients with chest pain [J].

Brennan, M ;

Penn, MS ;

Van Lente, F ;

Nambi, V ;

Shishehbor, MH ;

Aviles, RJ ;

Goormastic, M ;

Pepoy, ML ;

McErlean, ES ;

Topol, EJ ;

Nissen, SE ;

Hazen, SL .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (17) :1595-1604

[8] Preprocedural serum levels of C-reactive protein predict early complications and late restenosis after coronary angioplasty [J].

Buffon, A ;

Liuzzo, G ;

Biasucci, LM ;

Pasqualetti, P ;

Ramazzotti, V ;

Rebuzzi, AG ;

Crea, F ;

Maseri, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 34 (05) :1512-1521

[9] Widespread coronary inflammation in unstable angina [J].

Buffon, A ;

Biasucci, LM ;

Liuzzo, G ;

D'Onofrio, G ;

Crea, F ;

Maseri, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (01) :5-12

[10]

BUSTI C, 2009, INT EMERG MED

← 1 2 3 4 5 →