Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring

被引：22

作者：

Ivarsson, SA ^{[1
]}

Ackefors, M ^{[1
]}

Carlsson, A ^{[1
]}

Ekberg, G ^{[1
]}

Falorni, A ^{[1
]}

Kockum, I ^{[1
]}

Landin-Olsson, M ^{[1
]}

Lernmark, A ^{[1
]}

Lindberg, B ^{[1
]}

Sundkvist, G ^{[1
]}

Svanberg, L ^{[1
]}

机构：

[1] Malmo Univ Hosp, Dept Pediat, S-20502 Malmo, Sweden

来源：

AUTOIMMUNITY | 1997年 / 26卷 / 04期

关键词：

glutamic acid decarboxylase; islet cell autoantibodies; autoimmunity; placental transfer; HLA; pregnancy;

D O I：

10.3109/08916939709008032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab) and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmo, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8% ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependent diabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.

引用

页码：261 / 269

页数：9

共 46 条

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