Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract

被引：74

作者：

Jacoby, Peter ^{[1
]}

Watson, Kelly ^{[1
]}

Bowman, Jacinta ^{[1
]}

Taylor, Amanda ^{[1
]}

Riley, Thomas V. ^{[1
]}

Smith, David W. ^{[1
]}

Lehmann, Deborah ^{[1
]}

机构：

[1] Univ Western Australia, Div Populat Sci, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6872, Australia

来源：

VACCINE | 2007年 / 25卷 / 13期

基金：

英国医学研究理事会;

关键词：

longitudinal data analysis; bacterial carriage; respiratory viruses;

D O I：

10.1016/j.vaccine.2006.09.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Otitis media (OM) is a major burden for all children, particularly for Australian Aboriginal children. Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae and viruses (including rhinovirus and adenovirus) are associated with OM. We investigated nasopharyngeal microbial interactions in 435 samples collected from 79 Aboriginal and 570 samples from 88 non-Aboriginal children in Western Australia. We describe a multivariate random effects model appropriate for analysis of longitudinal data, which enables the identification of two independent levels of correlation between pairs of pathogens. At the microbe level, rhinovirus infection was positively correlated with carriage of S. pneumoniae, H. influenzae and M. catarrhalis, and adenovirus with M. catarrhalis. Generally, there were positive associations between bacterial pathogens at both the host and microbe level. Positive viral-bacterial associations at the microbe level support previous findings indicating that viral infection can predispose an individual to bacterial carriage. Viral vaccines may assist in reducing the burden of bacterial disease. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2458 / 2464

页数：7

共 35 条

[1] NASOPHARYNGEAL COLONIZATION DURING THE 1ST YEAR OF LIFE [J].