Therapeutic strategies for rheumatoid arthritis

被引:673
作者
Smolen, JS
Steiner, G
机构
[1] Univ Vienna, Dept Internal Med 3, Div Rheumatol, A-1090 Vienna, Austria
[2] Austrian Acad Sci, Ctr Mol Med, A-1090 Vienna, Austria
[3] Lainz Hosp, Ctr Rheumat Dis, Dept Med 2, A-1130 Vienna, Austria
关键词
D O I
10.1038/nrd1109
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Recent years have seen considerable advances in our understanding of both the clinical and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better recognition of the natural history of the disease, the development and validation of outcome measures for clinical trials and, consequently, innovative trial designs. In parallel, basic research has provided clues to the pathogenic events underlying rheumatoid arthritis, and advances in biotechnology have facilitated the development of new classes of therapeutics. Here, we summarize the fruits of these advances: innovative approaches to the use of existing, traditional disease-modifying antirheumatic drugs; novel agents approved very recently; and further avenues that are presently under investigation or which are of more distant promise.
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收藏
页码:473 / 488
页数:16
相关论文
共 267 条
  • [1] Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage
    Abramson, SB
    Amin, A
    [J]. RHEUMATOLOGY, 2002, 41 (09) : 972 - 980
  • [2] Alahari SK, 2002, INT REV CYTOL, V220, P145
  • [3] The rheumatoid arthritis patient in the clinic: comparing more than 1300 consecutive DMARD courses
    Aletaha, D
    Smolen, JS
    [J]. RHEUMATOLOGY, 2002, 41 (12) : 1367 - 1374
  • [4] Aletaha D, 2002, J RHEUMATOL, V29, P1631
  • [5] A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    Alexopoulou, L
    Pasparakis, M
    Kollias, G
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (10) : 2588 - 2592
  • [6] Interleukin 6 is required for the development of collagen-induced arthritis
    Alonzi, T
    Fattori, E
    Lazzaro, D
    Costa, P
    Probert, L
    Kollias, G
    De Benedetti, F
    Poli, V
    Ciliberto, G
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (04) : 461 - 468
  • [7] Interleukin-1 receptor antagonist: Role in biology
    Arend, WP
    Malyak, M
    Guthridge, CJ
    Gabay, C
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 : 27 - 55
  • [8] ARINGER M, 2003, TARGETED THERAPIES R, P404
  • [9] Armant MA, 2002, GENOME BIOL, V3
  • [10] Awane M, 1999, J IMMUNOL, V162, P5337