Acidocalcisomes - Conserved from bacteria to man

被引：352

作者：

Docampo, R ^{[1
]}

de Souza, W

Miranda, K

Rohloff, P

Moreno, SNJ

机构：

[1] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA

[2] Univ Georgia, Ctr Trop & Global Emerging Dis, Athens, GA 30602 USA

[3] Univ Illinois, Dept Pathobiol, Urbana, IL 61802 USA

[4] Univ Illinois, Ctr Zoonoses Res, Urbana, IL 61802 USA

[5] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil

[6] Univ Estadual Norte Fluminense, Lab Biol Celular & Tecidual, Campos, Brazil

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 03期

关键词：

D O I：

10.1038/nrmicro1097

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from prokaryotes to eukaryotes. Aciclocalcisomes were first described in trypanosomaticls and have been characterized in most detail in these species. Acidocalcisomes have been linked with several functions, including storage of cations and phosphorus, polyphosphate metabolism, calcium homeostasis, maintenance of intracellular pH homeostasis and osmoregulation. Here, we review acidocalcisome ultrastructure, composition and function in different trypanosomatids and other organisms.

引用

页码：251 / 261

页数：11

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