Antibody landscapes after influenza virus infection or vaccination

被引：336

作者：

Fonville, J. M. ^{[1
,2
,3
]}

Wilks, S. H. ^{[1
,2
]}

James, S. L. ^{[1
,2
]}

Fox, A. ^{[4
,5
]}

Ventresca, M. ^{[1
]}

Aban, M. ^{[6
]}

Xue, L. ^{[6
]}

Jones, T. C. ^{[1
,2
]}

Le, N. M. H. ^{[4
,5
]}

Pham, Q. T. ^{[7
]}

Tran, N. D. ^{[7
]}

Wong, Y. ^{[8
]}

Mosterin, A. ^{[1
,2
]}

Katzelnick, L. C. ^{[1
,2
]}

Labonte, D. ^{[9
]}

Le, T. T. ^{[7
]}

van der Net, G. ^{[3
]}

Skepner, E. ^{[1
,2
]}

Russell, C. A. ^{[2
,10
]}

Kaplan, T. D. ^{[11
]}

Rimmelzwaan, G. F. ^{[3
]}

Masurel, N. ^{[3
]}

de Jong, J. C. ^{[3
]}

Palache, A. ^{[12
]}

Beyer, W. E. P. ^{[3
]}

Le, Q. M. ^{[7
]}

Nguyen, T. H. ^{[7
]}

Wertheim, H. F. L. ^{[4
,5
,13
]}

Hurt, A. C. ^{[6
,14
]}

Osterhaus, A. D. M. E. ^{[3
]}

Barr, I. G. ^{[6
]}

Fouchier, R. A. M. ^{[3
]}

Horby, P. W. ^{[4
,5
,13
]}

Smith, D. J. ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England

[2] World Hlth Org WHO Collaborating Ctr Modeling Evo, Cambridge CB2 3EJ, England

[3] Erasmus MC, Dept Virosci, NL-3015 CE Rotterdam, Netherlands

[4] Oxford Univ Clin Res Unit, Hanoi, Vietnam

[5] Wellcome Trust Major Overseas Programme, Hanoi, Vietnam

[6] Peter Doherty Inst Infect & Immun, Victorian Infect Dis Reference Lab, WHO Collaborating Ctr Reference & Res Influenza, Melbourne, Vic 3000, Australia

[7] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam

[8] Univ Oxford, Museum Nat Hist, Oxford OX1 3PW, England

[9] Univ Cambridge, Dept Zool, Insect Biomech Grp, Cambridge CB2 3EJ, England

[10] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[11] Bobblewire Com, St Louis, MO 63112 USA

[12] Abbott Labs, NL-1380 DA Weesp, Netherlands

[13] Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford OX3 7BN, England

[14] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia

来源：

SCIENCE | 2014年 / 346卷 / 6212期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ORIGINAL ANTIGENIC SIN;

D O I：

10.1126/science.1256427

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.

引用

页码：996 / 1000

页数：5

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