Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial

被引:318
作者
Viljanen, M
Savilahti, E
Haahtela, T
Juntunen-Backman, K
Korpela, R
Poussa, T
Tuure, T
Kuitunen, M
机构
[1] Univ Helsinki, Skin & Allergy Hosp, Helsinki 00250, Finland
[2] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
[3] Valio Res & Dev, Helsinki, Finland
[4] Univ Helsinki, Inst Biomed, Helsinki, Finland
[5] STAT Consulting, Tampere, Finland
关键词
atopic dermatitis; food allergy; infants; Lactobacillus GG; probiotic; treatment;
D O I
10.1111/j.1398-9995.2004.00514.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Probiotic bacteria are suggested to reduce symptoms of the atopic eczema/dermatitis syndrome (AEDS) in food-allergic infants. We aimed to investigate whether probiotic bacteria have any beneficial effect on AEDS. Methods: Follow-up of severity of AEDS by the Severity Scoring of Atopic Dermatitis (SCORAD) index in 230 infants with suspected cow's milk allergy (CMA) receiving, in a randomized double-blinded manner, concomitant with elimination diet and skin treatment, Lactobacillus GG (LGG), a mixture of four probiotic strains, or placebo for 4 weeks. Four weeks after the treatment, CMA was diagnosed with a double-blind placebo-controlled (DBPC) milk challenge in 120 infants. Results: In the whole group, mean SCORAD (at baseline 32.5) decreased by 65%, but with no differences between treatment groups immediately or 4 weeks after the treatment. No treatment differences were observed in infants with CMA either. In IgE-sensitized infants, however, the LGG group showed a greater reduction in SCORAD than did the placebo group, -26.1 vs-19.8 (P = 0.036), from baseline to 4 weeks after the treatment. Exclusion of infants who had received antibiotics during the study reinforced the findings in the IgE-sensitized subgroup. Conclusion: Treatment with LGG may alleviate AEDS symptoms in IgE-sensitized infants but not in non-IgE-sensitized infants.
引用
收藏
页码:494 / 500
页数:7
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