Site-selective DNA photocleavage involving unusual photoinitiated tautomerization of chiral tridentate vanadyl(V) complexes derived from N-salicylidene α-amino acids

被引：57

作者：

Chen, CT ^{[1
]}

Lin, JS

Kuo, JH

Weng, SS

Cuo, TS

Lin, YW

Cheng, CC

Huang, YC

Yu, JK

Chou, PT

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei, Taiwan

[2] Tamkang UNiv, Dept Chem, Taipei, Taiwan

[3] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 24期

关键词：

D O I：

10.1021/ol048156h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The titled vanadyl(V) complexes serve as efficient reagents for cleaving supercoiled plasmid DNA by photoinitiation. Complex 3d, derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, exhibits a unique wedge feature, inducing a site-selective photocleavage at the C22-T23 of the bulge backbone for a HIV-27 DNA system at 0.1-5 muM. Transient absorption experiments for 3d indicate the involvement of LMCT with concomitant tautomerization, leading to an o-quinone-methide V-bound hydroxyl species responsible for the cleavage profiles.

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页码：4471 / 4474

页数：4

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