Meteoritic Cα-Methylated α-amino acids and the homochirality of life:: Searching for a link

被引：25

作者：

Crisma, M

Moretto, A

Formaggio, F

Kaptein, B

Broxterman, QB

Toniolo, C

机构：

[1] Univ Padua, Inst Biomol Chem, CNR, I-35131 Padua, Italy

[2] Univ Padua, Dept Chem, I-35131 Padua, Italy

[3] Adv Synth & Catalysis, DSM Res, Life Sci, NL-6160 MD Geleen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 48期

关键词：

amino acids; chemical evolution; chirality; helical structures; peptides;

D O I：

10.1002/anie.200460908

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catch a falling star: Peptides from chiral, Cα-methylated α-amino acids (see scheme) found in L enantiomeric excess in meteorites show diastereoselectivity when reacting with racemic proteinogenic amino acids. Accordingly, the prebiotic soup of proteinogenic amino acids may have evolved into a chirally unbalanced system, eventually seeding the homochirality of life.

引用

页码：6695 / 6699

页数：5

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