Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis

被引：128

作者：

Toulis, Konstantinos A. ^{[1
]}

Goulis, Dimitrios G. ^{[1
]}

Venetis, Christos A. ^{[2
]}

Kolibianakis, Efstratios M. ^{[2
]}

Negro, Roberto ^{[3
]}

Tarlatzis, Basil C. ^{[2
]}

Papadimas, Ioannis ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol,Sch Med, Thessaloniki 56403, Greece

[2] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1, Human Reprod Unit,Med Sch, Thessaloniki 56403, Greece

[3] Azienda Osped, Dept Endocrinol, I-73100 Lecce, Italy

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2010年 / 162卷 / 04期

关键词：

ANTITHYROID ANTIBODIES; OVARIAN HYPERSTIMULATION; LEVOTHYROXINE TREATMENT; ASSISTED REPRODUCTION; INCREASED PREVALENCE; PREGNANCY; FERTILIZATION; HYPOTHYROIDISM; DISEASE; AUTOANTIBODIES;

D O I：

10.1530/EJE-09-0850

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective: To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF. Design: Meta-analysis of observational studies. Patient(s): Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis. Main outcome measure: Miscarriage risk ratio (RR). Secondary outcome measures: Clinical pregnancy rate and delivery rate. Result(s): Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42-2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups. Conclusion: Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.

引用

页码：643 / 652

页数：10

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